Abstract
Analysis of DEL selection results requires the generation of large DNA sequence data sets and the conversion of DNA sequence to chemical structure. SAM and BAM formats are the generic formats for storing sequence alignment results. However, such formats are not directly applicable for analysis of DEL selection results due to the lack of reference sequences. In this protocol, reference sequences are constructed from DEL structure files using the central dogma of molecular biology analogy. Enabling the use of SAM and BAM formats drastically facilitates data access while also reducing data storage requirements and permits the efficient translation of DNA sequence to chemical structure of DEL compounds.
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