Abstract
Low oxygen concentration (hypoxia) promotes cancer evolution, tumor angiogenesis and tumor metastasis. Under hypoxic conditions cancer cells undergo genetic and adaptive changes in regulation of translation that facilitate production of proteins involved in tumor angiogenesis, cancer cell survival, proliferation and invasion. Hence, the translation machinery in cancer cells exposed to low oxygen levels is a candidate therapeutic target. This chapter focuses at the role of hypoxia in cancer biology vis-a-vis translation and its regulation.
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