Abstract
BackgroundThe Indian Takayasu Clinical Activity Score (ITAS2010) was developed in 2010 as an assessment tool for disease activity in patients with Takayasu arteritis (TA). It has since been widely used in different studies and in clinical practice for the management of patients with TA. The present study aims to translate the ITAS2010 into Brazilian Portuguese language and to validate it for use in clinical practice in Brazil.MethodsFor this cross-sectional study, the ITAS2010 was translated in accordance with the guidelines described by Beaton et al. and then applied with 27 patients with TA on three assessments by two rheumatologists working independently. To measure interrater agreement, the assessments were performed on the same day within approximately 1 hour. One of the rheumatologists performed a second evaluation of patients with TA within 7 to 14 days to measure intrarater agreement.ResultsThe correlation coefficient for the ITAS2010 score between the two raters was high (r = 0.916; p < 0.0001), as well as the intraclass correlation coefficient (ICC) [0.918 with a 95% confidence interval (95CI): 0.828–0.962]. The correlation coefficient and the ICC for intrarater agreement were moderate for ITAS2010 (r = 0.633; p < 0.0001 and ICC = 0.594; 95CI: 0.292–0.790). The ITAS2010 at baseline was compared with the physician’s global assessment (PGA) and with Kerr’s criteria for detecting disease activity in TA. Higher ITAS2010 scores were observed in patients with active and grumbling/persistent disease than in those presenting inactive disease according to the PGA [1.5 (0.0–3.0) vs. 0.0 (0.0–0.0); p = 0.0025]. Patients with active disease according to the Kerr’s criteria had also higher ITAS2010 scores than those considered in remission [3.0 (3.0–7.0) vs. 0.0 (0.0–0.0); p = 0.0068].ConclusionsThe Brazilian Portuguese version of the ITAS2010 is a valid and reproducible tool for the assessment of disease activity in TA and it is an additional tool for the routine evaluation of Brazilian patients with TA.
Highlights
The Indian Takayasu Clinical Activity Score (ITAS2010) was developed in 2010 as an assessment tool for disease activity in patients with Takayasu arteritis (TA)
Kerr’s criteria or the National Institutes of Health (NIH) criteria were proposed to assess disease activity in TA based on the onset of new disease manifestations, altered erythrocyte sedimentation rate (ESR) and new angiographic lesions [5]
Kerr’s criteria, have proven insensitive to disease activity in TA, since 61% of asymptomatic patients at follow-up had developed angiographic abnormalities in previously unaffected vascular territories, and active arterial inflammation was observed in 44% of patients with TA who were thought to be in remission and underwent arterial bypass surgery [5]
Summary
The Indian Takayasu Clinical Activity Score (ITAS2010) was developed in 2010 as an assessment tool for disease activity in patients with Takayasu arteritis (TA). It has since been widely used in different studies and in clinical practice for the management of patients with TA. Kerr’s criteria or the NIH criteria were proposed to assess disease activity in TA based on the onset of new disease manifestations, altered erythrocyte sedimentation rate (ESR) and new angiographic lesions [5] These criteria are only qualitative and they have been widely used in clinical practice and in studies evaluating patients with TA [6]. Kerr’s criteria, have proven insensitive to disease activity in TA, since 61% of asymptomatic patients at follow-up had developed angiographic abnormalities in previously unaffected vascular territories, and active arterial inflammation was observed in 44% of patients with TA who were thought to be in remission and underwent arterial bypass surgery [5]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
