Abstract
Editorial summaryGenomic medicine has considerable potential to provide novel diagnostic and therapeutic solutions for patients who have molecularly complex diseases and who are not responding to existing therapies. To bridge the gap between genomic medicine and clinical practice, integration of various data types, resources, and joint international initiatives will be required.
Highlights
Genomic medicine has considerable potential to provide novel diagnostic and therapeutic solutions for patients who have molecularly complex diseases and who are not responding to existing therapies
Promise and pitfalls of genomic medicine, focusing on genetic alterations An early, successful example of a drug that targets somatic genetic alterations was imatinib, a tyrosine kinase inhibitor that is used for the treatment of chronic myeloid leukemia patients who have a translocation that results in the formation of a constitutively active BCR-ABL fusion kinase [2]
(2019) 11:9 epidermal growth factor receptor (EGFR) with EGFR inhibitors, and the treatment of melanomas bearing mutated BRAF with BRAF inhibitors [2]. These successful examples have spurred concerted efforts to generalize genomic approaches to the treatment of disease, including those based at the National Cancer Institute (NCI), the National Institutes of Health (NIH), and several European and Asian centers
Summary
Genomic medicine has considerable potential to provide novel diagnostic and therapeutic solutions for patients who have molecularly complex diseases and who are not responding to existing therapies. To bridge the gap between genomic medicine and clinical practice, integration of various data types, resources, and joint international initiatives will be required.
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