Transition‐Metal‐Free Synthesis of an Aryl Boronate Ester through Base‐Mediated Boryl Substitution of an Aryl Halide with a Silylborane

Abstract

Abstract This chapter describes the procedure for transition‐metal‐free synthesis of an aryl boronate ester through base‐mediated boryl substitution of an aryl halide with a silylborane. It presents some of the important points to be considered, the conditions that need to be maintained, characterization data, and the reagents required, as well as the techniques used and the equipment setup that are vital to carrying out the process. The chapter also describes the hazards associated with working with chemicals and the ways to deal with these hazards. Organoboron compounds are highly versatile building blocks in modern organic chemistry because they can be readily transformed into a wide variety of different functional groups. Reactions of boron electrophiles with carbon nucleophiles such as Grignard reagents or organolithium reagents are popular methods for the preparation of organoboron compounds.