Abstract

The article is devoted to the issue of transitional states in child psychoneurology, based on the general concept of a continuum of transitional states from normal variants to severe chronic diseases. The article discusses borderline psychoneurology disorders associated with mitochondrial dysfunction and various genetic defects. A significant passage is devoted to convulsive states and epilepsy. The autism spectrum analyzed both as a aggregate of nosologies and in combination with epilepsy. The author proposes the concept of quasicontinuum of cognitive development in the spectrum of child autism. There are presented the transitions of various forms of hysteria. Also the authors provide the data on the similar etiology of impaired coordination and cerebral palsy, which can be considered as a single continual process. As possible methods of dividing the continuum into separate forms there are works on the so-called signal features and a dynamics model for estimating time limits of transition states, also the operators to determine the value of factors characterizing transition states, are presented.

Highlights

  • Federal Research Center “Computer Science and Control”, Moscow, Russia; Pirogov Russian National Research Medical University, Moscow, Russia

  • The article is devoted to the issue of transitional states in child psychoneurology, based on the general concept of a continuum of transitional states from normal variants to severe chronic diseases

  • The article discusses borderline psychoneurology disorders associated with mitochondrial dysfunction and various genetic defects

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Summary

Митохондриальная патология и генетические дефекты

Митохондрии связываются с клеткой посредством митохондриальных ретроградных сигнальных путей, которые позволяют органелле контролировать транскрипцию ядерного гена

Функциональная дезадаптация
Судорожные состояния
Эпилепсия и аутизм
Континуум истерии
Нарушения координации и ДЦП
Сигнальные признаки и анализ динамики патологии

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