Transitional Cell Carcinoma arising in Ovarian Cystic Teratoma: A Rare Case Report

Abstract

Mature cystic teratoma (MCT) is one of the commonest germ cell neoplasms of the ovary, but only 1–2% gets transformed into a malignant neoplasm. Amongst these, squamous cell carcinoma and adenocarcinoma are most commonly documented in the literature. The development of transitional cell carcinoma is exceptionally uncommon, and only eight cases have been reported in the literature till date as per our knowledge. Here, we report a case of transitional cell carcinoma arising in a dermoid cyst of right ovary in a 48-year-old woman who presented with history of abdominal mass since 3–4 months. Grossly, the ovary was cystic. Microscopically, the cyst wall revealed classic features of MCT and papillary fronds at one place showing features of papillary transitional cell carcinoma (TCC). IHC showed positivity for CK7 and CK20 and negativity for WT-1. When TCC is found as a component of MCT, the origin of the carcinoma should be evaluated.