Abstract
Abstract. Systemic lupus erythematosus (SLE) is a autoimmune disorders with multisystems and organs such as kidney, lung and heart et. al. The abnormal functions of B cells induced the pathogenesis and pathological progression of this disease. The therapeutic strategies targeting B cells have been used clinically to treat SLE, achieved encouraging result. However, some patients have side effects such as infection caused by excessive humoral immune suppression. Sc-RNA sequencing technology can sequence the overall RNA in the level of single cell, aiming to classify cells, thus achieving to target B cell subgroups precisely. This article utilized transcriptome sequencing data of single cell from PBMCs in the GEO database, and subsequently analysed for dimensionality reduction clustering and data screening using R packages. Ultimately, the author discovered highly variable genes and related pathways of SLE samples transitional B cells, providing possible directions to explore SLE related treatment candidates in future.
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