Transition of cardiometabolic status and the risk of type 2 diabetes mellitus among middle-aged and older Chinese: A national cohort study.

Abstract

ABSTRACTAims/IntroductionThe cardiometabolic index (CMI) has been proposed as a novel indicator of cardiometabolic status. This study aimed to investigate the effects of CMI and its longitudinal transitions on the development of type 2 diabetes mellitus in middle‐aged and older Chinese.Materials and MethodsWe used data from the China Health and Retirement Longitudinal Study (2011–2018). CMI was calculated as the product of the waist circumference to height ratio and the triglyceride to high‐density lipoprotein cholesterol ratio. At baseline in 2011, the subjects were classified into low‐ and high‐CMI groups, and then divided into four transition patterns during follow‐up, i.e. maintained‐low, low‐to‐high, high‐to‐low, and maintained‐high CMI. The hazard ratios (HRs) of different transition patterns for type 2 diabetes mellitus were calculated using multivariable Cox frailty models.ResultsDuring 2011–2018, 7,347 participants were included. Participants with a high‐CMI at baseline had a significantly higher risk of new‐onset type 2 diabetes mellitus than those with a low‐CMI (HR = 1.78, 95% CI:1.55–2.05). For subjects with a low‐CMI at baseline, the risk of developing type 2 diabetes mellitus increased by 75% if their CMI status changed to high during follow‐up (HRlow‐to‐high = 1.75, 95% CI:1.35–2.28). Meanwhile, for subjects with a maintained‐high CMI, no significant risk reduction for type 2 diabetes mellitus was found when their CMI changed to low status (HRhigh‐to‐low = 0.77, 95% CI: 0.58–1.01).ConclusionsBaseline CMI levels and longitudinal CMI transition patterns were associated with a higher risk of type 2 diabetes mellitus. Early anti‐lipid measures should be taken to prevent type 2 diabetes mellitus in middle‐aged and older Chinese.