Transition Metal-Catalyzed Transformations of P(O)—H Bonds

Abstract

Organophosphorus compounds are of high importance in organic synthesis, catalysis, biochemistry, pharmaceuti- cals, and material science. In this account, we summarize our recent studies on transition metal-catalyzed transformations of P(O)—H compounds, mainly the regio- and stereo-selective additions of P(O)—H bonds to carbon—carbon unsaturated com- pounds, asymmetric hydrophosphorylation reactions, and oxidative/dehydrogenative cross-couplings of P(O)—H bonds with C—H and heteroatom—H bonds. These new reactions provided a series of efficient and atom economic, general and green ways for the preparation of a variety of versatile organophosphorus compounds. Mechanistic aspects related to the catalytic processes are also discussed. Keywords transition metal catalysts; P(O)—H compounds; regio- and stereo-selective addition; carbon—carbon unsaturated compounds; oxidative/dehydrogenative cross-coupling; carbon—H and heteroatom—H compounds; fine organophosphorus compounds 有机膦化合物在有机合成、有机催化、不对称催化、