Abstract
Systematic study of the transition metal-catalyzed aldol reactions of certain prochiral ketones with methyl isocyanoacetate has been made. High diastereoselectivity (80–98% de) of these condensations, leading to methyl (4 R ∗,5 R ∗)-4,5-dihydro-5,5-(disubstituted)-4-oxazolecaboxylates was shown to be controlled by the nature of both catalyst and substituents on the starting ketone.
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