Abstract
A series of tetrahydrosalophen Schiff bases have been prepared from the reaction of two equivalents of salicylaldehyde with one equivalent o-phenylenediamine derivatives followed by reduction with NaBH4. The Co (II), Ni (II), Cu (II) and Zn (II) complexes of these ligands have been prepared. All the synthesized ligands and metal complexes were characterized by IR, 1H and 13C-NMR, MS, XRD, TGA, UV-Visible, Fluorescence and elemental analysis. The Preliminary results of antituberculosis study showed that the salophen schiff bases 2a-2b demonstrated very good antituberculosis activity while the tetrahydrosalophen schiff bases 3a-3i showed moderate activity. Among the tested metal complexes 4a was found to be most active with minimum inhibitory concentration (MIC) of 6.25 μg/ml against Mycobacterium tuberculosis (H37 RV strain) ATCC No-27294.
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