Transition Metal Salt Catalyzed Direct Three‐Component Mannich Reactions of Aldehydes, Ketones, and Carbamates: Efficient Synthesis of N‐Protected β‐Aryl‐β‐Amino Ketone Compounds.

Abstract

The transition metal salt-catalyzed direct three-component Mannich reactions of aryl aldehydes, aryl ketones, and carbamates are described. The RuCl3·xH2O-, AuCl3−PPh3-, and AuCl3-catalyzed direct Mannich reactions led to the synthesis of N-protected β-aryl-β-amino ketones, and the results create new possibilities for exploiting the transition metal salt-catalyzed direct Mannich reaction and facile synthesis of β-amino ketone libraries.