Transition Metal‐Free α‐C(sp3)H Bond Functionalization of Amines by Oxidative Cross Dehydrogenative Coupling Reaction: Simple and Direct Access to C‐4‐Alkylated 3,4‐Dihydroquinazoline Derivatives

Abstract

AbstractA transition metal‐free catalytic system has been developed for the cross dehydrogenative coupling of amines with nitroalkanes under mild condition employing potassium iodide/tert‐butyl hydrogen peroxide catalytic system. This methodology was further extended for the construction of biologically important N‐heterocycles, namely, 3,4‐dihydroquinazoline derivatives. This novel strategy provides a simple, efficient, and direct access to 4‐alkyl‐3,4‐dihydroquinazoline derivatives.