Transition metal complexes of s-triazine derivative: new class of anticonvulsant, anti-inflammatory, and neuroprotective agents

Abstract

A new series of transition metal complexes of 2,4-bis(indolin-3-one-2-ylimino)-6-phenyl-1,3,5-triazine) (BIPTZ) have been synthesized. The structural features of BIPTZ and metal(II) complexes were investigated using elemental analyses, magnetic susceptibility, molar conductance, mass, IR, UV–Vis, 1H NMR, 13C NMR, CV, and ESR spectral studies. Electronic absorption spectra and magnetic susceptibility measurements of the complexes predict their geometry. The redox behavior of the copper(II) complexes has been studied by cyclic voltammetry. All the synthesized compounds may serve as potential photoactive materials as indicated from their characteristic fluorescence spectrum. The Schiff base and its metal complexes were screened for anticonvulsant and anti-inflammatory activities in vivo. The metal(II) complexes are potent agents in treating neurochemical and behavioral abnormalities seen in Parkinson’s diseased (PD) mice than free ligand.