Transition Metal Complexes of Omeprazole An Anti-Ulcerative Drug

Suman Malik,Supriya Das,Bharti Jain

doi:10.26850/1678-4618eqj.v36.3.2011.p31-36

Abstract

Omeprazole (OME) is a proton pump inhibitor (PPI). PPI’s have enabled to improve the treatment of various acidpeptic disorders. OME is a weak base and it can form several complexes with transition and non-transitions metal ions. In the present paper, we are describing series of trantion metal complexes of omeprazole i.e.,5-methoxy-2[(4methoxy-3,5dimethyl-2-pyridinyl)methylsulfinyl]–1H–benzimidazole with CuII, MnII, CoII, NiII, FeII, ZnII and HgII. These complexes were characterized by elemental analysis, molar conductance, IR, NMR, magnetic susceptibility, UV-visible spectral studies, ESR, SEM and X-ray diffraction. Based on the above studies, the ligand behaves as bidentate O, N donor and forms coordinate bonds through C=N and S=O groups .The complexes were found to non-electrolytic in nature on the basis of low values of molar conductance . Analytical data and stochiometry suggest ligand metal ratio of 2:1 for all the complexes. Electronic Spectra and Magnetic susceptibility measurements reveal octahedral geometry for Mn(II),Co(II), Ni(II),Fe(II) and Cu(II) complexes and tetrahedral for Hg(II) and Zn(II) complexes. Ligands and their metal complexes have been screened for their antibacterial and antifungal activities against bacteria Pseudomonas, Staphylococcus Aureus and fungi Aspergillus niger and A. flavous.

Highlights

A peptic ulcer, known as PUD or peptic ulcer disease is an ulcer of an area of the gastrointestinal tract that is usually acidic and extremely painful .Ulcer results from a complex interplay of acid and chronic inflammation induced by H
Pylori infection[1,2] .Most of the times, ulcers are associated with Helicobacter pylori, a spiral-shaped bacterium that lives in the acidic environment of the stomach
The present paper reports the synthesis, characterization and antimicrobial activity of a very common pump inhibitor (PPI), omeprazole, with first row transition metals like CuII, MnII, CoII, NiII, FeII, ZnIIandHgII

Summary

Introduction

A peptic ulcer, known as PUD or peptic ulcer disease is an ulcer of an area of the gastrointestinal tract that is usually acidic and extremely painful .Ulcer results from a complex interplay of acid and chronic inflammation induced by H. To confirm the ligand-metal ratio, conductometric titrations using mono-variation method were carried out at 21 0C. The complexes were synthesized by mixing the solutions (70% methanol) of metal salt with that of ligand in 1:2 molar ratios respectively.

Results

Conclusion