Transition metal complexes of diclofenac with potentially interesting anti-inflammatory activity

Abstract

An overview is given of the results of metal ion–diclofenac interactions. Several complexes have been synthesized at the University of Ioannina. Binuclear complexes, [Cu(L) 2(H 2O)] 2·2H 2O and [CuL 2(S)] 2 where S is H 2O, EtOH, DMSO, (CH 3) 2CO and DMF, and mononuclear complexes, [MnL 2(H 2O)], [FeL 2(H 2O) 2], [CoL 2(H 2O) 2]·0.5H 2O, [CoL 2(H 2O)], [NiL 2(H 2O) 2]·2H 2O, [NiL 2] and [PdL 2]·2H 2O, have been characterized by spectroscopy, X-ray crystallography and electrochemical studies. The catalytic activity of these complexes was correlated to the reduction potential. Some of the complexes of diclofenac exhibit very promising anti-inflammatory activity and act as antioxidant compounds, a property that is absent from diclofenac.