Transition metal-catalyzed synthesis of N, O−Heterocycles via C–H functionalization

Abstract

Heterocyclic compounds are widely present in the core structures of several natural products, pharmaceuticals, and agrochemicals. Over the years, synthesis of heterocyclic products via C–H activation in a step and atom-economical manner has won impressive advances as a newly emerging synthetic strategy. Recently, the strategy of transition metal catalyzed C–H bond activation of arenes without using prefunctionalized starting materials has emerged as a powerful tool to create the different class of heterocycles. This review is mainly focused on the recent developments in the synthesis of heterocyclic compounds such as benzofurans, indoles, quinolinones and quinolines with diverse coupling partners via inter and intramolecular C–H functionalization reactions. The methodologies described in this review are preferably exogenous directing group free approaches. Togati Naveen was born in 1987 in Telangana, India. He studied chemistry at KMDC, Khammam and received his BSc in 2008. After completing his MSc at Kakatia University he received his Ph. D from IIT Bombay (India) in 2017 under the supervision of Prof. Debabrata Maiti. After postdoctoral studies at CSIR-IICT Hyderabad he joined the department of applied chemistry of SVNIT Surat as an assistant professor in 2019. His research interests are focused on the development of new and sustainable synthetic methodologies. • In this review we have presented an overview of C-H functionalization strategies to construct novel N, O- heterocycles. • Synthesis of heterocycles with diverse coupling partners has been showcased by using widely available starting materials. • This review majorly focused on exogenous directing group free approaches for the synthesis of N, O -heterocycles.