Transition‐Metal‐Catalyzed Hydroamination and Carboamination Reactions of Anthranilic Allenamides as a Route to 2‐Vinyl‐ and 2‐(α‐Styryl)quinazolin‐4‐one Derivatives

Abstract

Abstract2‐Vinyl‐ and 2‐(α‐styryl)quinazolin‐4‐ones have been synthesized by intramolecular gold‐catalyzed hydroamination and palladium‐catalyzed carboamination of anthranilic allenamides, easily prepared by prototropic isomerization of the corresponding propargylamides. These procedures, which lead to N‐Boc‐protected quinazolinones, represent a more flexible alternative to the reported palladium‐catalyzedamination of anthranilic allylamides, achievable only from N‐tosylallylamides.