Abstract
AbstractA green electrochemical C(sp2)−H trifluoromethylation of imidazo[1,2‐a]pyridines by engaging Langlois’ reagent is reported. This oxidative regioselective CF3‐functionalization strategy operates under open atmosphere, in an undivided cell and at ambient temperature. Regioselective C−CF3 bond formation was achieved exclusively by applying this mild protocol exhibiting broad functional group compatibility affording the desired product up to 79% isolated yield. Mechanistic studies indicated a radical pathway for this electrochemical redox transformation.
Published Version
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