Abstract
An interesting idea is whether transient tachypnea of the newborn (TTN) is associated with the development of wheezing syndromes in early life. This question was investigated by Liem et al in the Sage study. Data were obtained from the Population Health Research Data Repository at the Manitoba Centre for Health Policy, and more than 12,000 children from the province of Manitoba were studied. Of these children, 2.4% developed TTN, and infants with TTN were found to be at significantly increased risk of a wheezing disorder in childhood. Many of us believe that TTN is a self-limiting disease with no significant sequelae. This finding challenges that assumption. The authors discuss whether the association is due to maternal asthma, is a risk factor for TTN, whether genetic factors are at play, or whether environmental factors such as early exposure to antibiotics may be a factor.
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