Abstract
Meeting abstracts Adoptive transfer of haploidentical natural killer (NK) cells can induce remissions in patients with AML. Despite lymphodepleting chemotherapy failure may result from suppression by host regulatory T cells (Treg). We report outcomes of 57 refractory AML patients treated with
Highlights
Adoptive transfer of haploidentical natural killer (NK) cells can induce remissions in patients with AML
We report outcomes of 57 refractory AML patients treated with cyclophosphamide and fludarabine followed by haploidentical NK cells and exogenous IL-2 to facilitate NK proliferation
NK cell-enriched product characteristics are described for three production methods
Summary
Adoptive transfer of haploidentical natural killer (NK) cells can induce remissions in patients with AML. Transient regulatory T-cell (Treg) depletion with IL-2 diphtheria toxin fusion protein enhances clearance of acute myeloid leukemia by haploidentical natural killer (NK) cells Veronika Bachanova*, Sarah Cooley, Todd Defor, Michael R Verneris, Bin Zhang, David McKenna, Julie Curtsinger, Angela Panoskaltsis-Mortari, Dixie Lewis, Keli Hippen, Philip McGlave, Daniel Weisdorf, Bruce R Blazar, Jeffrey S Miller From Society for Immunotherapy of Cancer 28th Annual Meeting National Harbor, MD, USA.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
