Abstract

Objective of study: Aplasia of the erythropoiesis without any other affection of bone marrow function, is seen as two major conditions in children: a congenital chronic form (Diamond Blackfan anaemia, DBA) and a transient form (transient erythroblastopenia of childhood, TEC). Aplasia may also be caused by parvovirus B 19 in children as well as in adults, but anaemia is usually diagnosed in case of coexistant haemolytic disease. While heredity in DBA is well established from studies of large families and its corresponding genedefect recently has been discovered, TEC has seldom been described in more than one member of a family. Does the occurence of TEC in siblings indicates a hereditary connection?

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