Abstract
We have developed a novel, operator-friendly, nanothermite reaction actuator which generates transient pressures comprised of a shock wave superimposed on a broad pressure pulse to facilitate intranuclear molecular transport. The actuator demonstrates the delivery of ∼70 kDa FITC-Dextran into chicken cardiomyocytes with cytoplasmic delivery efficiency greater than 90%, maximum intranuclear delivery efficiency of 84%, and cell survival rates exceeding 95% in minimum operating pressure conditions. Tunable nanothermite reactions enable versatile pressure generating characteristics which can extend the technology to a spectrum of biomedical molecular delivery applications.
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