Abstract
Transient hyperphosphatasemia of infancy and childhood (TH) is a temporary and isolated increase of serum alkaline phosphatase (ALP; EC 3.1.3.1) activity occurring without obvious cause during the first years of life. Despite several reports about this phenomenon, the origin of TH remains obscure. Over a period of 8 years (1992–1999), we detected 194 cases of TH in 106 boys and 88 girls. The hyperphosphatasemia was discovered fortuitously during routine investigations in outpatient and inpatient departments of a children’s hospital with a capacity of 500 beds. A wide variety of clinical disorders was associated with this condition (gastrointestinal diseases, 24%; respiratory infections, 21%; congenital anomalies and …
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