Abstract
Some authors have suggested that the syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) results from an immunological response directed against a viral agent. Here we report a case of HaNDL in an immunocompetent 19-year-old male that could support this hypothesis.
Highlights
The syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) is a benign and rare disease that was first described in the eighties [1, 2]
We report here a case of HaNDL that occurred in a 19year-old immunecompetent male who evinced serological evidence of isolated IgM antibodies to the Epstein-Barr virus (EBV) viral capsid antigen (VCA)
The simultaneous occurrence of HaNDL and isolated IgM VCA could support the concept that an inappropriate immune reaction underlies the development of the neurological symptoms
Summary
The syndrome of transient headache and neurological deficits with cerebrospinal fluid lymphocytosis (HaNDL) is a benign and rare disease that was first described in the eighties [1, 2]. Some authors have suggested that the HaNDL results from an immunological response directed against a viral agent. We report here a case of HaNDL that occurred in a 19year-old immunecompetent male who evinced serological evidence of isolated IgM antibodies to the Epstein-Barr virus (EBV) viral capsid antigen (VCA). The simultaneous occurrence of HaNDL and isolated IgM VCA could support the concept that an inappropriate immune reaction underlies the development of the neurological symptoms
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