Transient elastography assessment of liver allograft fibrosis in pediatric transplant recipients.

Abstract

TE measures liver stiffness to assess fibrosis. Its use in post-transplant patients was reported in few small pediatric studies. We evaluated TE ability to predict liver graft fibrosis in a large cohort while comparing it to the performance of APRI and FIB-4. We also investigated the effect of graft type on LSMs. Patients at Boston Children's Hospital who underwent LT and LSM≤1year from biopsy (2007-2018) were eligible. Ninety-four patients (45%M) aged 1-21years (89%<18years; 13%<2years) were eligible. Median time between transplant/biopsy and LSM was 5.1years and 52days, respectively. Thirty-nine percent received whole-liver grafts, 54% TV grafts, and 6% as part of MV. At LSM, median ALT was 25 [IQR 16-33]IU/L. Twenty-one percent had METAVIR≥F2. LSM was statistically higher among those with significant fibrosis (METAVIR≥F2) compared to those with METAVIR F0/F1 (median [IQR] 7.5 [4.6, 13.6] vs 5.1 [4.0, 6.4]kPa, respectively) (P=.005 by Wilcoxon rank-sum test). APRI and FIB-4 distributions were not different across METAVIR stages. The AUROC for LSM was 0.71 (95% CI 0.56-0.85) with an optimal cut-point of 6.5kPa. Graft type had no influence on the AUROC for LSM. TE is useful for assessing significant graft fibrosis in children and young adult LT recipients and performs better than APRI and FIB-4. TV grafts demonstrate similar correlation with histology as whole-liver grafts.