Abstract
A new approach to modeling transitions to epileptic state and back in the brain thalamocortical system is proposed. Since no specific mechanism for termination of spike-wave discharges (SWDs, the main encephalographic manifestation of absence seizures) was found based on signal analysis, we consider SWDs to be long transients after external stimulus. We constructed mesoscale models — ensembles of FitzHugh–Nagumo neurons connected based on anatomical laws for thalamocortical system. In a class of 88 connectivity matrices for models consisting of 14 nodes we showed that the long quasiregular mostly synchronous transients are typical in some parameter region.
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