Abstract
The effect on CO 2 storage and elimination of variations in the slope and intercept of the ventilatory response to CO 2 curve was examined. Theoretical and experimental results show that although CO 2 elimination rate following a transient ventilatory disturbance in decreased at low ventilatory response slopes, this decrease can be compensated by elevated P CO 2 intercepts, or thresholds. Conversely, high CO 2 elimination rate following a ventilatory disturbance due to a high ventilatory response slope can be off-set by a depressed P CO 2 threshold. The results suggest that elevated thresholds which often accompany depressed ventilatory response slopes may be part of a compensatory mechanism for minimizing transient hypercapnia and acidosis.
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