Transient changes in refractive error and corneal tomography after 24-h continuous monitoring of intraocular pressure patterns with a contact lens sensor

Abstract

To evaluate changes in refractive error and corneal tomographic measurements after 24-h monitoring of intraocular pressure patterns with a contact lens sensor (CLS). Prospective, longitudinal, observational study. Fourteen eyes of 14 consecutive patients who underwent 24-h CLS monitoring were enrolled. The objective spherical equivalent (SE) refractive error was measured using automated refraction and keratometry. The axial power, instantaneous power, and corneal thickness at the central, paracentral, midperipheral, and peripheral cornea were measured with swept-source anterior-segment optical coherence tomography. Measurements were performed at baseline, immediately after monitoring, and at follow-up visits 2-4days after monitoring. The myopic SE increased significantly (P < 0.001) from - 5.1 ± 4.2 to - 6.0 ± 4.0, D after 24-h monitoring with a CLS and returned to the premonitoring level at the second visit (- 5.3 ± 4.4 D, P = 0.315). Decreases in the midperipheral and peripheral axial powers and the paracentral instantaneous power and increases in the central instantaneous power and peripheral corneal thickness occurred after CLS monitoring. Twenty-four-hour monitoring with a CLS resulted in significant increases in the myopic refractive error and corneal central steepening and midperipheral flattening. Although these changes are transient and do not negate the clinical merits of the CLS, clinicians should be aware of these potential adverse events. Three-dimensional evaluation of corneal deformation with anterior segment optical coherence tomography is a powerful tool for assessing and improving the safety, tolerability, and accuracy of CLS devices.