Transglutaminase 2 Knock-out Protects Against Airway Inflammation And Tissue Remodeling In Ova-specific Allergic Asthma In Mice

Abstract

Transglutaminase 2 (TGase 2) is over-expressed in a variety of inflammatory diseases including allergic asthma. TGase 2 inhibitors block TGase 2 over-expression. This study aimed to investigate whether TGase 2-/- protects against airway inflammation and tissue remodeling associated with OVA-induced allergic asthma in mice. C57BL/6 or TGase 2-/- mice were sensitized and challenged with OVA to induce asthma. OVA-specific serum IgE and leukotrienes (LTs) levels were measured by ELISA, and the recruitment of inflammatory cells into BAL fluid or lung tissues was stained with Diff-Quik and H & E, goblet cell hyperplasia by PAS.