Abstract
Objectives: Dyslipidemia, insulin resistance and increased oxidative stress are important components of metabolic syndrome (MS). Transcription factor Nrf2 (nuclear factor erythroid 2-related factor-2) plays a key role in cellular defence againts oxidative stress, participates in metabolic homeostasis and in lipid metabolism. To test the role of Nrf2 in lipid metabolism disturbances in the pathogenesis of MS, we derived spontaneously hypertensive rat (SHR) transgenic line with ubiquitous expression of the Nrf2 gene (SHR-Nrf2).
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