Abstract
Alcoholic liver disease (ALD) is one of the leading causes of morbidity and mortality from hepatic complications. C1q/TNF-related protein 3 (CTRP3) is an adiponectin paralog and, in male mice, increased levels of circulating CTRP3 prevents ALD. Therefore, the purpose of this study was to replicate the observed hepatoprotective effect of elevated circulating CTRP3 levels in female mice. Twelve-week-old female wildtype and CTRP3 overexpressing transgenic mice were fed the Lieber-DeCarli alcohol-containing liquid diet (5% vol/vol) for 6 weeks. Unlike the previous study with male mice, CTRP3 overexpression provided no attenuation to alcohol-induced hepatic lipid accumulation, cytokine production, or overall mortality. In conclusion, there appears to be a clear sex-specific effect of CTRP3 in response to alcohol consumption that needs to be explored further.
Highlights
Chronic liver disease is the 12th leading cause of morbidity and mortality worldwide [1,2,3,4,5,6,7,8]
The C1q/TNF-related protein 3 (CTRP3) transgenic overexpression (Tg) mouse strain was developed on the C57Bl/6J background with the carboxy-terminal FLAG epitope (DYKDDDDK)-tagged CTRP3 expression driven by the CMV early enhancer/chicken-actin (CAG) promoter as described previously [19]
The main purpose of this study was to determine whether transgenic overexpression of CTRP3 would prevent hepatic lipid accumulation in female mice
Summary
Chronic liver disease is the 12th leading cause of morbidity and mortality worldwide [1,2,3,4,5,6,7,8]. Almost half of liver-related deaths are due to alcohol over-consumption [6], referred to as alcoholic liver disease (ALD). The two major causes of excess lipid buildup in the liver result from a high-fat diet (referred to as nonalcoholic fatty liver disease (NAFLD) and/or overconsumption of alcohol, ALD. Both NAFLD and ALD have similar histopathological structures [8,9,10]. The amount of alcohol consumption is generally related to the severity of the disease, the reasons for the progression of ALD to chronic hepatitis and alcoholic cirrhosis in subset of patients are unknown
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