Abstract
Cell proliferation by asbestos fibers is a consequence of early asbestos-induced injury to pulmonary epithelial and mesothelial cells and may be critical to the development of fibroproliferative diseases.1,2 In mesothelial and alveolar type II epithelial cells, epidermal growth factor (EGF) and crocidolite asbestos are potent mitogens. Asbestos fibers cause aggregation of the EGF receptor (EGFR)3 and increased levels of EGFR steady-state messenger RNA and protein.4 Phosphorylation of the EGFR by asbestos fibers is causally related to increased phosphorylation and activity of extracellular signal-regulated protein kinases (ERKs) 1 and 2 and c-fos protooncogene expression.
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