Transgenic models in the study of AIDS dementia complex.

Abstract

A significant number of HIV-1 infected individuals develop central nervous system (CNS) complications which can include motor difficulties, behavioral abnormalities, and cognitive impairments. These symptoms can progress to nearly vegetative end stage clinical presentations of paralysis and severe dementia (see PRICE and PERRY 1994, for detailed review). Variably referred to as “AIDS dementia complex,” “HIV encephalopathy,” and “HIV-1 associated cognitive/motor complex,” this syndrome has been observed most often in the late stages of systemic HIV-1 infection. Nevertheless, the CNS is an early target of infection (Ho et al. 1985; Goudsmit et al. 1986; Marshall et al. 1988; Resnick et al. 1988; Appleman et al. 1988; Mcarthur et al. 1988; Elovaara et al. 1990). In pédiatric patients, CNS disease occurs more frequently and its accompanying clinical syndrome has been termed “progressive encephalopathy” (for review, see PRICE and PERRY 1994). The transgenic models discussed in this chapter are pertinent to both pédiatric and adult forms of HIV-1 -related brain damage.KeywordsHuman Immunodeficiency VirusGlial Fibrillary Acidic ProteinFeline Immunodeficiency VirusTransgenic ModelCentral Nervous System PathologyThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.