Transgenic Animal Models of Bladder Cancer

Abstract

Traditional animal models for cancer research represent an excellent experimental tool in bridging the gap between pre-clinical and clinical studies. The advances in gene transfer technologies allow the generation of transgenic animal models through the integration of the gene of interest into the animal models through gene transfer methods. Overcoming the limitations of traditional animal models, transgenic animal models are beneficial for studying carcinogenesis with respect to the genes. Besides, the utilization of transgenic animal models is also necessary for the development of novel targeted therapy. Bladder cancer (BC) is the most common cancer type worldwide and effective therapies targeting BC are urgently needed. Thus, with the delineation of molecular signatures of BC pathogenesis, the research involving transgenic animal models of BC will facilitate the development of clinical medicine, thereby improving the clinical outcome of BC patients in the future.