Transgenesis of Bioluminescence (BL) Gene and Its Potential Use for Malaria Residual Transmission Issue and Other Vector Borne Diseases: New Considerations for Vector and Vector Borne Diseases (VBD) Control

Abstract

The present article considers the potential of transgenesis of the bioluminescent gene for malaria and other vector borne diseases (VBD) control. Vector control is an important component of every vector control operations for the vector borne disease control. Actually the bioluminescence phenomena and the green fluorescent protein GPF open great field of researches and “On December 10, 2008 Osamu Shimomura, Martin Chalfie and Roger Tsien were awarded the Nobel Prize in Chemistry for "the discovery and development of the green fluorescent protein, GFP". Bio-molecular technologies and transgenesis open the field for getting BL mosquitoes such as Plasmodium (several references) for “Transmission Reducing Activity” (TRA) without any hazard on human beings and ecological level. For exemple BL mosquitoes would be of paramount importance for mark-release-recapture becoming easier to implement and giving more relevant and reliable data on relation between density (size of the population) and distance (and wind) as the vector population size decrease with increasing distance from the source of production (breeding site) or release point. BL appeared already of great interest to understand the relation vector/parasite and to assess transmission intensity. Our idea is to genetically produce “Bioluminescent Mosquitoes” allowing a better identification of their presence, behavior, densities, infected specimens, risk of transmission before/after vector control operations which could be greatly improved thanks to the targeting of mosquitoes resting site or flight range and any other biological component.