Abstract
To determine if binge ethanol consumption before ovulation affects oocyte quality, gene expression, and subsequent embryo development. Binge levels of ethanol were given twice weekly for 6 months, followed by a standard in vitro fertilization cycle and subsequent natural mating. National primate research center. Adult female rhesus monkeys. Binge levels of ethanol, given twice weekly for 6 months before a standard in vitro fertilization cycle with or without embryo culture. With in vivo development, ethanol treatment continued until pregnancy was identified. Oocyte and cumulus/granulosa cell gene expression, embryo development to blastocyst, and pregnancy rate. Embryo development in vitro was reduced; changes were found in oocyte and cumulus cell gene expression; and spontaneous abortion during very early gestation increased. This study provides evidence that binge drinking can affect the developmental potential of oocytes even after alcohol consumption has ceased.
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