Abstract
In patients who have received multiple transfusions of universal donor blood, a hemolytic transfusion reaction can develop upon subsequent transfusion with blood of their hereditary group. By careful microscopic examination of the cell grouping, the hereditary group of such patients can be determined. Residual transfused antibody to the patient's hereditary group should be assessed by similar examination of the serum grouping and by further testing the serum grouping with antiglobulin serum. When no antibody is demonstrable, group-specific blood should be given; otherwise group O packed cells minimize the quantity of antibody that is added to the patient's circulation. If microscopic inspection of the RH 0 (D) grouping reveals unagglutinated cells, Rh 0 negative blood should be used until antibody detection tests clarify the patient's Rh 0 status. Experience with six patients has proved this protocol satisfactory.
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