Transfusion transmissible infections in blood donors: A 7-year study in central Gujarat

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<b>Context:</b> One of the major adverse effects of blood transfusion is transfusion transmissible infections (TTIs). Serological testing can help to reduce, but not eliminate occurrences of TTIs. Study of TTIs in different blood donor groups help to find safe blood for patients. <b>Aims:</b> The aim of this study was to determine the prevalence and trends in TTIs in voluntary and replacement blood donors. <b>Settings and Design:</b> Voluntary and replacement blood donors were studied for TTIs over the duration of 7 years. TTIs were documented with particulates like gender and type of donation (voluntary or replacement). <b>Materials and Methods:</b> Blood donation taken after predonation examination. Tests for TTIs carried out from donated blood and results were documented. <b>Statistical Analysis Used:</b> Data entered into Microsoft Excel sheets and studied for prevalence, trend, and odds ratio. <b>Results:</b> Total blood units taken during the period from 2007 to 2013 were 15,368. 93.1% were male donors and 6.9% were female donors. Prevalence of TTIs was 0.72%. Human immunodeficiency virus, hepatitis B surface antigen, hepatitis C virus, and syphilis were detected in 0.14%, 0.38%, 0.06%, and 0.14% of donors, respectively. No female donors had TTI. TTIs in voluntary donors (VDs) and replacement donors were 0.64% and 1.15%. <b>Conclusions:</b> Outcome of the study shows increasing trend for total blood donation, voluntary donations, and female blood donors. All TTIs were reducing except syphilis. To provide safe blood to patients, blood donation from VDs and female donors should be encouraged.