Transfusion Effectiveness of Single Donor Apheresis Platelet over Random Donor Platelet; A Comparative Study

Abstract

Background: Platelet transfusion performs a key function in treatment for patients with thrombocytopenia. The use of single donor apheresis platelet results in better post-transfusion recovery & survival than random donor platelet. Activation of platelet depends on their preparation and storage and this may be one of the factors responsible for storage related change in platelet membrane proteins. In transfusion medicine laboratory we commonly prepare platelet concentrates from whole blood, platelet rich plasma, buffy coat and single donor plateletpheresis. Objective: The aim of the study was to evaluate the transfusion effectiveness of single donor apheresis platelet over random donor platelet. Methods: This is an observational study. This study was carried out on 125 dengue patients the find out about the population including male and female patients in the Department of Transfusion Medicine, Bangabandhu Sheikh Mujib Medical University, Chittagong Medical College Hospital, Bangladesh and Samorita Hospital & Medical College, Dhaka, Bangladesh. The duration of the period from July 2021 to December 2022. The period from data was entered in MS Excel and Statistical analysis was done using SPSS-24. Results: The total study population was 125 patients aged 10 – 40 years, 17(13.6%) were ≤10 years, 49(39.2%) were 11-20 years, 37(29.6%) were 21-30 years and 22(17.6%) were 31-40 years. Sex distribution of the population where, 85(68.0%) were male and 40(32.0%) were female. Conclusion: Single-donor apheresis platelet transfusions produced higher platelet counts, whereas random donor platelet also effective in preventing hemorrhage.