Transfusion Dependent Anemia, and Cytopenia Secondary to Parvovirus B19 Infection as the First Manifestation of X-linked Hyper IgM Immunodeficiency Syndrome in Two Male Patients in Their Third Decade of Life

Abstract

We describe two male patients with unique mutation of CD40L gene, unlike classic presentation of X-linked hyper IgM immunodeficiency syndrome (XHIGM syndrome), both were healthy until presenting in their early twenties with a challenging symptomatic transfusion-dependent anemia, investigations confirmed XHIGM syndrome with concurrent chronic Parvovirus infection.