Abstract
Posterior capsular opacification (PCO) is a most common complication of modem cataract surgery.The prevention of PCO is the key to ensure long-term efficacy of cataract surgery.The proliferation,migration,and epithelial-mesenchymal transition of intraoperative residual lens epithelial cells are cellular basis of PCO.Transforming growth factor β,(TGF-β) participates in the development of PCO by regulating lens epithelial cells proliferation,migration,differentiation and apoptosis.It is envisaged that the regulation of TGF-β,TGF-β receptor and its downstream pathway (Smad proteins and matrix metalloproteinases) can prevent PCO.By the means of conjunctival sac daub and anterior chamber injection,TGF-β antibodies,matrix metalloproteinase inhibitors and connective tissue growth factor antisense oligonucleotides or specific antibodies may become the new ways of preventing PCO. Key words: posterior capsule opacification; transforming growth factor beta; lens epithelial cells
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