Abstract
PurposeTransforming growth factor-β2 is known to be present at elevated levels in the aqueous humor of patients with primary open angle glaucoma (POAG) and diabetes but not in uveitis-related secondary glaucoma. We investigated total TGF-β2 levels and levels of the active form of TGF-β2 in the aqueous humor of eyes with different types of glaucoma.MethodsThe concentration of the total and active form of TGF-β2 was measured in 63 patients with primary open angle glaucoma, neovascular glaucoma complicated with diabetes (NVG), and secondary open angle glaucoma complicated with uveitis (SOAG) using a double antibody 'sandwich-indirect' ELISA method.ResultsThe levels of total TGF-β2 in the aqueous samples of POAG, NVG, and SOAG were elevated. The levels of active TGF-β2 in the aqueous samples of POAG, and NVG were also elevated, whereas the level of active TGF-β2 was within the normal range in the aqueous samples of SOAG.ConclusionsThese results suggest that the level of TGF-β2 may play a role in the pathology of various types of glaucoma.
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