Abstract
Transforming growth factor (TGF)-β plays essential roles in embryogenesis, particularly during periods of morphogenesis. Some of the same embryological mechanisms are reiterated in the adult during the normal processes of tissue remodeling and repair and aberrantly in various pathological processes, including carcinogenesis. This chapter highlights the new advances in the understanding of the complex biology of TGF-β and discusses the chemistry of TGF-β. The broad range of biological activities of TGF-β makes it highly likely that other peptide activities—purified by presumably novel and specific assays—will result from TGF-β once their amino acid sequence is determined. TGF- β1 and 2 are two homologous forms of a homodimeric peptide with molecular weight of 25,000. Every chain of the peptide contains 112 amino acids of which nine are cysteine residues. The chapter reviews the structure of TGF-β1 and 2 and TGF-β gene family. The biological activities of the members of the TGF-β family are described in the chapter. The chapter further reviews the regulation of gene activity by TGF-β, antibodies to TGF-β, and role of TGF-β in embryogenesis, tissue repair and remodeling, and carcinogenesis and other proliferative diseases.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
