Abstract
Meninges synthesize parathyroid hormone-related protein (PTHrP) and transforming growth factor (TGFβ1). Both factors control the activity of the glial enzyme dipeptidyl peptidase II (DPP II): TGFβ1 induces the secretion of enzyme activity by cultivated astrocytes in a dose dependent manner. The maximal effect is achieved with a concentration of 10 ng/ml and is dependent on the time of incubation. PTHrP itself has no effect on the release of DPP II activity but considerably reduces the effect of TGFβ1. It is assumed that DPP II influences the course of cicatrization after penetrating injuries of the brain and thus, meninges control glial scarring by the release of TGFβ1 and PTHrP.
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