Abstract
Abstract3,17‐Dioxo‐Δ4‐androsten‐19‐al (II) is a suitable starting material for the preparation of estrane derivatives.Autoxidation gives the corresponding 10β‐hydroperoxide III, which can be converted to estrone (V) by reduction and aromatization.Treatment with alkaline reagents under various conditions can produce 3‐oxo‐Δ4‐ (VI), 3‐oxo‐Δ5(10) ‐ (VII) and 2‐hydroxymethylene‐3‐oxo‐Δ5(10) ‐ estrene (VIII) derivatives.
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