Abstract
Callender and Lajtha1 observed that little or no conversion of megaloblasts to normoblasts occurred when pernicious anaemia marrow was cultivated in pernicious anaemia serum by itself or together with vitamin B12. However, if bone marrow is cultivated in pernicious anaemia serum containing vitamin B12 and normal gastric juice or in normal serum with vitamin B12 megaloblasts are partly converted into normoblasts within twenty-four hours. Swan et al. 2 did not find this influence of vitamin B12 and gastric juice, but Astaldi and Cardinali3 have recently confirmed the findings of Callender and Lajtha1.
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