Abstract
Regulation of hematopoietic stem and progenitor cells (HSPCs) self-renewal, expansion, and differentiation is an inevitable process for normal hematopoiesis in the bone marrow (BM) niche, where leukemia cells are born, proliferate and occupy the microenvironment. External mediators such as extracellular vesicles (EVs) shed from leukemia cells, are one of the most important cell to cell communicators, and leading to phenotype and genotype modification and subsequently, fate of the cell. This review highlights recent evidences about the possible roles of leukemia derived-EVs on maintenance, proliferation, and death of HSPCs in a same microenvironment as leukemia cells. In addition, it focuses on mechanisms involved in the transformation of BM niche in favor of leukemia microenvironment remodeling by leukemia derived-EVs.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
