Abstract
Hamster embryo fibroblasts were transformed by the SV40-Adeno 7 hybrid virus. The transfomed cells, denoted KE SP2, contained the SV40 tumor (T) antigen demonstrable by both complement-fixation reaction and immunofluorescence tests, but no infectious virus. Attempts to rescue the SV40-derived marker from the transformed cells failed. The KE SP2 cells induced tumors in adult hamsters; sera from these animals contained antibodies reacting with the SV40 T antigen, but not with the SV40 or Adeno 7 viral (V) antigens. Immunofluorescence tests with monkey kidney cells infected with the prototype Adeno 7 (Gomen) virus revealed also the presence of antibodies reactive with the Adeno 7 T antigen. Cells containing the determinant for its synthesis were not lost after one passage in hamster or after a long history of passagesin vitro.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
